Folic acid deficiency in patients who use metformin hydrochloride: A narrative review
Keywords:
Folate, Methylfolate, Biguanides, Type 2 diabetes mellitus, Megaloblastic anemiaAbstract
This paper presents a review that brings together, presents, and discusses studies on the relationship between plasma folic acid levels and metformin hydrochloride (MET) use. This is a narrative review, with the following guiding question: Do patients using MET have folic acid deficiency? The literature search was conducted using Pubmed, Scielo, LILACS, and Science Direct as databases. 9930 articles were found, with a total of five selected to answer the guiding question. In conclusion, the use of MET can reduce serum levels of folic acid, in which they present themselves as an adverse event caused by the use of the drug. Because MET is a widely used drug, it is of paramount importance that there is monitoring of the serum levels of folic acid of patients by health professionals, in order to prevent them from reaching the levels of deficiency.
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