• Fabiana Aguena Sales Lapa Unoeste
  • Silvia Franco Andrade UNOESTE
  • Eduardo Roberto Gervazoni Unoeste
  • Vanessa Massumi Kaneko Unoeste
  • Osimar Carvalho Sanches Unoeste
  • Luis Roberto Almeida Gabriel Filho Unoeste
Palavras-chave: transmissible venereal tumor, ivermectin, vincristine, cytology, histopathology


The transmissible venereal tumor (TVT) is a contagious neoplasm of round cells that frequently affect dogs. The treatment consists of chemotherapy being more effective the vincristine alone, however the resistance emergence to this agent due multidrug resistance of the P-glycoprotein (P-gp), a transporter protein encoded by the MDR1 gene, has been taking the association with other drugs. Recent studies demonstrated the antitumoral effect of the avermectins when associated to the vincristine in the treatment of some neoplasms. Therefore, the objective of the present study was to compare the effectiveness of standard treatment of TVT with vincristine only as compared to combined treatment with vincristine and ivermectin, evaluated through number of applications of the two protocols, histopathological and cytological analysis from 50 dogs diagnosed with TVT during the period of 2007 to 2010. The combined protocol significant reduces the number of applications and cytological and histopathological findings collaborate with the hypothesis that the combination of vincristine and ivermectin promotes faster healing than the use of vincristine alone. Combination treatment with vincristine and ivermectin could be in the future an excellent therapeutic alternative for the treatment of TVT for probably reducing the resistance to vincristine, simultaneously reducing the cost of TVT treatment and a faster recovery of the dog.


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Biografia do Autor

Fabiana Aguena Sales Lapa, Unoeste
Mestrado em Ciência Animal da UNOESTE
Silvia Franco Andrade, UNOESTE
Professora Titular de Farmacologia e Terapêutica Veterinária Professora Titular de Clínica Médica de Pequenos Animais Autora do livro Manual de Terapêutica Veterinária
Eduardo Roberto Gervazoni, Unoeste
Faculdade de Medicina Veterinária
Vanessa Massumi Kaneko, Unoeste
Mestrado em Ciência Animal
Osimar Carvalho Sanches, Unoeste
Departamento de Anatomia Patológica
Luis Roberto Almeida Gabriel Filho, Unoeste
Departamentode Estatística
Como Citar
Sales Lapa, F. A., Andrade, S. F., Gervazoni, E. R., Kaneko, V. M., Sanches, O. C., & Gabriel Filho, L. R. A. (2012). HISTOPATHOLOGICAL AND CYTOLOGICAL ANALYSIS OF TRANSMISSIBLE VENEREAL TUMOR IN DOGS AFTER TWO TREATMENT PROTOCOLS. Colloquium Agrariae. ISSN: 1809-8215, 8(1), 36-45. Recuperado de http://revistas.unoeste.br/index.php/ca/article/view/657

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